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An artifact must be destroyed in some special way. Otherwise, it is impervious to damage.
Each artifact has a weakness by which its creation can be undone. Learning this weakness might require extensive research or the successful completion of a quest. The DM decides how a particular artifact can be destroyed. Some suggestions are provided here:
The artifact must be melted down in the volcano, forge, or crucible in which it was created.
The artifact must be dropped into the River Styx.
The artifact must be swallowed and digested by the tarrasque or some other ancient creature.
The artifact must be bathed in the blood of a god or an angel.
The artifact must be struck and shattered by a special weapon crafted for that purpose.
The artifact must be pulverized between the titanic gears of Mechanus.
The artifact must be returned to its creator, who can destroy it by touch.
